The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

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Re: sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrent miscarriage or implantation failure patients.

BACKGROUND The aneuploidy rate is higher in poor-quality sperm samples, which also have higher DNA fragmentation index values. The aim of this study was to assess the relationship between sperm DNA fragmentation in samples from infertile men belonging to couples with recurrent miscarriage or implantation failure and the aneuploidy rate in spermatozoa as well as in embryos from patients. METHO...

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O-8: Some Variations of the TSSK2 Gene May be Associated with Impaired Spermatogenesis

Background: Tssk2, a member of the testis specific serine/threonine kinase (TSSK) family, is expressed predominantly in the testis and crucial for the formation and function of the sperm cells in mouse. Targeted deletion of Tssk1 and 2 in male chimeric mice caused infertility due to haploinsufficiency of the genes. Therefore it is reasonable to postulate that mutations in its human homologue TS...

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ژورنال

عنوان ژورنال: Clinical Epigenetics

سال: 2020

ISSN: 1868-7075,1868-7083

DOI: 10.1186/s13148-020-00854-0